Proteomics is the interdisciplinary field focusing on the large-scale study of proteins. Proteins essentially organize and execute all functions within organisms. Today, the bottom-up analysis approach is the most commonly used workflow, where proteins are digested into peptides and subsequently analyzed using Tandem Mass Spectrometry (MS/MS). MS-based proteomics has transformed various fields in life sciences, such as drug discovery and biomarker identification. Today, proteomics is entering a phase where it is helpful for clinical decision-making. Computational methods are vital in turning large amounts of acquired raw MS data into information and, ultimately, knowledge.

The field of proteomics aims to study and understand the complex landscape of proteins present within a biological system.

The continued scaling of flash memory technology into smaller process nodes, combined with the increased information capacity of each flash cell (i.e, storing more bits per cell), has placed NAND flash memory at the forefront of modern storage technology.

Table 9 highlights interesting patterns observed in Figure 3. First, the same modification occurring at

The field of proteomics aims to study and understand the complex landscape of proteins present within a biological system.

AI clusters today are one of the major uses of High Bandwidth Memory (HBM). However, HBM is suboptimal for AI workloads for several reasons. Analysis shows HBM is overprovisioned on write performance, but underprovisioned on density and read bandwidth, and also has significant energy per bit overheads. It is also expensive, with lower yield than DRAM due to manufacturing complexity. We propose a new memory class: Managed-Retention Memory (MRM), which is more optimized to store key data structures for AI inference workloads. We believe that MRM may finally provide a path to viability for technologies that were originally proposed to support Storage Class Memory (SCM). These technologies traditionally offered long-term persistence (10+ years) but provided poor IO performance and/or endurance. MRM makes different trade-offs, and by understanding the workload IO patterns, MRM foregoes long-term data retention and write performance for better potential performance on the metrics important for these workloads.